National Institutes of Health: Synergistic control of acute respiratory pathogens by bacteriophage and the innate immune response (2019-2024)

The goal of this project (/w Laurent Debrabieux (Pateur Institute)) is to develop a model-based approach to synergistic control of acute respiratory infections caused by Pseudomonas aeruginosa, combining in vitro and mouse systems.

Army Research Office: Coevolutionary Dynamics and Control of Virus-Microbe Communities (2019-2022)

This project seeks to identify evolutionary network principles associated with resilient dynamics of ecological communities, including the influence of complex microbial communities associated with chronic respiratory infections using phage, small molecules, and combination approaches informed by control theory.

Simons Foundation: Eco-Evolutionary Theories of Viral Fitness on a Continuum from Lysis to Latency (2020-2024)…

The goal of this project is to combine principles of ecology, evolution, and nonlinear dynamics to develop eco-evolutionary theories of viral persistence with microbial cells and populations, and collaboratively examine how non-lytic infections re-shape the core structure and functioning of complex marine ecosystems.

Simons Foundation, Simons Collaboration on Ocean Ecology Processes: Viruses vs. zooplankton: quantifying the interplay between parasites and predators in the North Pacific Ocean (2014-2020)…

The goal of this project to develop models to characterize the role of lytic viruses in shaping microbial community structure in the North Pacific Subtropical Gyre. The focus of my work has been on antagonistic virus-microbe interactions, model-data fitting, data synthesis, and in the development of a new approach to light-drive size-structured community dynamics.

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