Microbes make up for being small by being very complicated. Nearly every habitat, whether soils, lakes, oceans, our gut, is teeming with microbes. What is there? What are they doing? We try and answer these questions at multiple scales by developing systems approaches to gene regulation, ecological models of interactions, and bioinformatic methods for community analysis. We envision the link between bioinformatics and systems biology as one that will continue to grow, and also hope to integrate the approach and perspective of theoretical ecology to the microbial world. Here is some of what we're up to:
- Quantitative theory of nonlinear effects of copy number variation on gene expression
- Formal approaches to bin and cluster environmental short sequence data
- Stoichiometric models of microbial grazing and parasitism.